Ion channel remodeling in gastrointestinal inflammation
HI Akbarali, E G. Hawkins, GR Ross… - Neurogastroenterology …, 2010 - Wiley Online Library
HI Akbarali, E G. Hawkins, GR Ross, M Kang
Neurogastroenterology & Motility, 2010•Wiley Online LibraryBackground Gastrointestinal inflammation significantly affects the electrical excitability of
smooth muscle cells. Considerable progress over the last few years have been made to
establish the mechanisms by which ion channel function is altered in the setting of
gastrointestinal inflammation. Details have begun to emerge on the molecular basis by
which ion channel function may be regulated in smooth muscle following inflammation.
These include changes in protein and gene expression of the smooth muscle isoform of L …
smooth muscle cells. Considerable progress over the last few years have been made to
establish the mechanisms by which ion channel function is altered in the setting of
gastrointestinal inflammation. Details have begun to emerge on the molecular basis by
which ion channel function may be regulated in smooth muscle following inflammation.
These include changes in protein and gene expression of the smooth muscle isoform of L …
Abstract
Background Gastrointestinal inflammation significantly affects the electrical excitability of smooth muscle cells. Considerable progress over the last few years have been made to establish the mechanisms by which ion channel function is altered in the setting of gastrointestinal inflammation. Details have begun to emerge on the molecular basis by which ion channel function may be regulated in smooth muscle following inflammation. These include changes in protein and gene expression of the smooth muscle isoform of L‐type Ca2+ channels and ATP‐sensitive K+ channels. Recent attention has also focused on post‐translational modifications as a primary means of altering ion channel function in the absence of changes in protein/gene expression. Protein phosphorylation of serine/theronine or tyrosine residues, cysteine thiol modifications, and tyrosine nitration are potential mechanisms affected by oxidative/nitrosative stress that alter the gating kinetics of ion channels. Collectively, these findings suggest that inflammation results in electrical remodeling of smooth muscle cells in addition to structural remodeling. Purpose The purpose of this review is to synthesize our current understanding regarding molecular mechanisms that result in altered ion channel function during gastrointestinal inflammation and to address potential areas that can lead to targeted new therapies.
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