N-acylethanolamines (NAEs) constitute a class of bioactive lipid molecules present in
animal and plant tissues. Among the NAEs, N-arachidonoylethanolamine (anandamide), N-
palmitoylethanolamine, and N-oleoylethanolamine attract much attention due to
cannabimimetic activity as an endocannabinoid, anti-inflammatory and analgesic activities,
and anorexic activity, respectively. In mammalian tissues, NAEs are formed from
glycerophospholipids through the phosphodiesterase-transacylation pathway consisting of …