Patients and animals with renal injury exhibit increased urinary excretion of
angiotensinogen. Although increased tubular synthesis of angiotensinogen contributes to
the increased excretion, we do not know to what degree glomerular filtration of systemic
angiotensinogen, especially through an abnormal glomerular filtration barrier, contributes to
the increase in urinary levels. Here, we used multiphoton microscopy to visualize and
quantify the glomerular permeability of angiotensinogen in the intact mouse and rat kidney …