Adoptive cellular therapy for cytomegalovirus infection following allogeneic stem cell transplantation using virus-specific T cells
S Mackinnon, K Thomson, S Verfuerth, K Peggs… - Blood Cells, Molecules …, 2008 - Elsevier
Adoptive transfer of virus-specific T cells offers the potential for accelerating reconstitution of
antigen-specific immunity and limiting the morbidity and mortality of viral infections following
allogeneic haematopoietic stem cell transplantation. However, the logistics of producing
virus-specific T cells and the risk of inducing graft-versus-host disease secondary to the
infusion of alloreactive clones have limited the application of cellular therapies. We report
the results in patients of pre-emptive and prophylactic therapy with cytomegalovirus-specific …
antigen-specific immunity and limiting the morbidity and mortality of viral infections following
allogeneic haematopoietic stem cell transplantation. However, the logistics of producing
virus-specific T cells and the risk of inducing graft-versus-host disease secondary to the
infusion of alloreactive clones have limited the application of cellular therapies. We report
the results in patients of pre-emptive and prophylactic therapy with cytomegalovirus-specific …