[HTML][HTML] Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft
I Koyama, O Nadazdin, S Boskovic, T Ochiai… - American journal of …, 2007 - Elsevier
Heterologous immunologic memory has been considered a potent barrier to tolerance
induction in primates. Induction of such tolerance for a previously transplanted organ may be
more difficult, because specific memory cells can be induced and activated by a
transplanted organ. In the current study, we attempted to induce tolerance to a previously
transplanted kidney allograft in nonhuman primates. The conditioning regimen consisted of
low dose total body irradiation, thymic irradiation, antithymocyte globulin, and anti-CD154 …
induction in primates. Induction of such tolerance for a previously transplanted organ may be
more difficult, because specific memory cells can be induced and activated by a
transplanted organ. In the current study, we attempted to induce tolerance to a previously
transplanted kidney allograft in nonhuman primates. The conditioning regimen consisted of
low dose total body irradiation, thymic irradiation, antithymocyte globulin, and anti-CD154 …
