Expression of Toll-like receptors 2 and 4 on human intestinal lymphatic vessels
S Kuroshima, Y Sawa, T Kawamoto, Y Yamaoka… - Microvascular …, 2004 - Elsevier
The Toll-like receptor (TLR) is a part of the innate immune system sensing pathogen-
associated molecular patterns (PAMPs). Recently, TLRs 2 and 4 have been demonstrated
for the ligand engagements, which result in the induction of cytokines. Here we investigated
the expression of TLRs 2 and 4 on lymphatic vessels producing cys–cys chemokine ligand
21 (CCL21) in the human small intestine. The specificity of antibodies to TLRs was tested on
a human monocyte leukemia cell line, umbilical vein endothelial cells (HUVEC), and …
associated molecular patterns (PAMPs). Recently, TLRs 2 and 4 have been demonstrated
for the ligand engagements, which result in the induction of cytokines. Here we investigated
the expression of TLRs 2 and 4 on lymphatic vessels producing cys–cys chemokine ligand
21 (CCL21) in the human small intestine. The specificity of antibodies to TLRs was tested on
a human monocyte leukemia cell line, umbilical vein endothelial cells (HUVEC), and …
