Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis
O Salvucci, G Tosato - Advances in cancer research, 2012 - Elsevier
Eph receptor tyrosine kinases and their Ephrin ligands represent an important signaling
system with widespread roles in cell physiology and disease. Receptors and ligands in this
family are anchored to the cell surface; thus Eph/Ephrin interactions mainly occur at sites of
cell-to-cell contact. EphB4 and EphrinB2 are the Eph/Ephrin molecules that play essential
roles in vascular development and postnatal angiogenesis. Analysis of expression patterns
and function has linked EphB4/EphrinB2 to endothelial cell growth, survival, migration …
system with widespread roles in cell physiology and disease. Receptors and ligands in this
family are anchored to the cell surface; thus Eph/Ephrin interactions mainly occur at sites of
cell-to-cell contact. EphB4 and EphrinB2 are the Eph/Ephrin molecules that play essential
roles in vascular development and postnatal angiogenesis. Analysis of expression patterns
and function has linked EphB4/EphrinB2 to endothelial cell growth, survival, migration …
