[HTML][HTML] Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development
T Force, JR Woodgett - Journal of biological chemistry, 2009 - ASBMB
Intensive study over the past 30 years has helped define the role of the GSK-3 (glycogen
synthase kinase-3) family in a variety of physiological and pathophysiological processes.
However, the majority of these studies have relied upon overexpression approaches or
nonselective small molecule inhibitors. Herein, we examine recent data derived from studies
in gene-targeted embryonic stem cells and knock-out mice in an attempt to define the role
these protein kinases play in critical decisions made by stem/progenitor cells and by early …
synthase kinase-3) family in a variety of physiological and pathophysiological processes.
However, the majority of these studies have relied upon overexpression approaches or
nonselective small molecule inhibitors. Herein, we examine recent data derived from studies
in gene-targeted embryonic stem cells and knock-out mice in an attempt to define the role
these protein kinases play in critical decisions made by stem/progenitor cells and by early …