Matriptase-2-and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression
JE Maxson, J Chen, CA Enns, AS Zhang - Journal of Biological Chemistry, 2010 - ASBMB
Hemojuvelin (HJV) is an important regulator of iron metabolism. Membrane-anchored HJV
up-regulates expression of the iron regulatory hormone, hepcidin, through the bone
morphogenic protein (BMP) signaling pathway by acting as a BMP co-receptor. HJV can be
cleaved by the furin family of proprotein convertases, which releases a soluble form of HJV
that suppresses BMP signaling and hepcidin expression by acting as a decoy that competes
with membrane HJV for BMP ligands. Recent studies indicate that matriptase-2 binds and …
up-regulates expression of the iron regulatory hormone, hepcidin, through the bone
morphogenic protein (BMP) signaling pathway by acting as a BMP co-receptor. HJV can be
cleaved by the furin family of proprotein convertases, which releases a soluble form of HJV
that suppresses BMP signaling and hepcidin expression by acting as a decoy that competes
with membrane HJV for BMP ligands. Recent studies indicate that matriptase-2 binds and …