Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2* 2 gene allele
GS Peng, YC Chen, TP Tsao, MF Wang… - Pharmacogenetics and …, 2007 - journals.lww.com
Objectives It has been well documented that although homozygosity of the variant aldehyde
dehydrogenase-2 (ALDH2) gene allele, ALDH2* 2, in Asians almost fully protects against
alcoholism, the heterozygosity only affords a partial protection to varying degrees. The full
protection against alcoholism has been ascribed to the low-amount of alcohol
hypersensitivity accompanied by a prolonged and large accumulation of acetaldehyde in
blood (Peng et al. Pharmacogenetics 1999; 9: 463− 476). The physiological basis for the …
dehydrogenase-2 (ALDH2) gene allele, ALDH2* 2, in Asians almost fully protects against
alcoholism, the heterozygosity only affords a partial protection to varying degrees. The full
protection against alcoholism has been ascribed to the low-amount of alcohol
hypersensitivity accompanied by a prolonged and large accumulation of acetaldehyde in
blood (Peng et al. Pharmacogenetics 1999; 9: 463− 476). The physiological basis for the …
