Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age
C Castorina, A Campisi, C Di Giacomo, V Sorrenti… - Neurochemical …, 1992 - Springer
Neurochemical research, 1992•Springer
In the present study, we have assayed the enzymatic activity of Cu, Zn− SOD, Mn− SOD,
GSH− Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene
levels and MDA formation were also determined. The conjugated diene levels in rat retina
were found to increase significantly with age, accompanied by a marked decrease in GSH−
Px and Cat activities. No agerelated change in MDA levels and in GSH-Red and G6PD
activity was found, whereas a significant increase in SOD activity was observed between 1 …
GSH− Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene
levels and MDA formation were also determined. The conjugated diene levels in rat retina
were found to increase significantly with age, accompanied by a marked decrease in GSH−
Px and Cat activities. No agerelated change in MDA levels and in GSH-Red and G6PD
activity was found, whereas a significant increase in SOD activity was observed between 1 …
Abstract
In the present study, we have assayed the enzymatic activity of Cu,Zn−SOD, Mn−SOD, GSH−Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene levels and MDA formation were also determined. The conjugated diene levels in rat retina were found to increase significantly with age, accompanied by a marked decrease in GSH−Px and Cat activities. No agerelated change in MDA levels and in GSH-Red and G6PD activity was found, whereas a significant increase in SOD activity was observed between 1 and 4 months. Decreased GSH−Px and Cat activity is related to increased lipid peroxidation with age.
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