Time-lapse analysis of aggregate formation in an inducible PC12 cell model of Huntington's disease reveals time-dependent aggregate formation that transiently …
B Gong, MCY Lim, J Wanderer, A Wyttenbach… - Brain research …, 2008 - Elsevier
Huntington's disease (HD) is a progressive neurodegenerative disease caused by a CAG
repeat expansion in the coding region of the HD gene. The translated polyglutamine
expansion causes the formation of insoluble aggregates in the brains of HD patients and
transgenic mouse models. However, the relationship between aggregate formation and
neuropathology remains unknown. We used fluorescent protein tagging and live-cell time-
lapse microscopy to study visible aggregate formation and its relationship to cell death in …
repeat expansion in the coding region of the HD gene. The translated polyglutamine
expansion causes the formation of insoluble aggregates in the brains of HD patients and
transgenic mouse models. However, the relationship between aggregate formation and
neuropathology remains unknown. We used fluorescent protein tagging and live-cell time-
lapse microscopy to study visible aggregate formation and its relationship to cell death in …