Decreased glucose effectiveness but not insulin resistance in glucose-tolerant offspring of Japanese non—insulin-dependent diabetic patients: A minimal-model …
K Doi, A Taniguchi, Y Nakai, H Kawamura, Y Higaki… - Metabolism, 1997 - Elsevier
K Doi, A Taniguchi, Y Nakai, H Kawamura, Y Higaki, H Yokoi, H Tanaka, J Fujitani, M Suzuki…
Metabolism, 1997•ElsevierThe aim of the study was to estimate insulin sensitivity (SI), insulin secretion, and glucose
effectiveness (SG) in 10 subjects with normal glucose tolerance (eight men and two women)
with a family history of non—insulin-dependent diabetes mellitus (NIDDM offspring). Ten
glucose-tolerant subjects (eight men and two women) without a family history of NIDDM
served as control subjects. All subjects were Japanese. They underwent a modified
frequently sampled intravenous glucose tolerance test (FSIGT): glucose (300 mg/kg body …
effectiveness (SG) in 10 subjects with normal glucose tolerance (eight men and two women)
with a family history of non—insulin-dependent diabetes mellitus (NIDDM offspring). Ten
glucose-tolerant subjects (eight men and two women) without a family history of NIDDM
served as control subjects. All subjects were Japanese. They underwent a modified
frequently sampled intravenous glucose tolerance test (FSIGT): glucose (300 mg/kg body …
The aim of the study was to estimate insulin sensitivity (SI), insulin secretion, and glucose effectiveness (SG) in 10 subjects with normal glucose tolerance (eight men and two women) with a family history of non—insulin-dependent diabetes mellitus (NIDDM offspring). Ten glucose-tolerant subjects (eight men and two women) without a family history of NIDDM served as control subjects. All subjects were Japanese. They underwent a modified frequently sampled intravenous glucose tolerance test (FSIGT): glucose (300 mg/kg body weight) was administered, and insulin (20 mU/kg over 5 minutes) was infused from 20 to 25 minutes after glucose. SI and SG were estimated by Bergman's minimal-model method. No significant difference was observed in body mass index (22.6 ± 1.5 v 21.5 ± 0.6 kg/m2) and fasting glucose (5.1 ± 0.1 v 5.2 ± 0.1 mol/L) and insulin (40.7 ± 6.3 v 42.6 ± 6.7 pmol/L). SI was not different between the two groups (0.83 ± 0.11 v 0.94 ± 0.15 × 10−1 · min−1 · pmol/L−1, P > .05). The acute insulin response to glucose (AIRgglucose) estimated by intravenous glucose tolerance testing was significantly lower in the offspring than in the normal controls (2,139 ± 265 v 3,438 ± 318 pmol/L · min, P < .05). The glucose disappearance rate (KG) and SG were significantly diminished in the offspring versus normal controls (KG, 1.50 ± 0.22 v 2.10 ± 0.15min−1, P < .05; SG, 0.016 v 0.003 ± 0.023 ± 0.002 min−1, P < .05). Thus, glucose-tolerant Japanese NIDDM offspring with normal insulin sensitivity are characterized by a reduced AIRglucose and diminished SG. This is the first report that glucose resistance but not insulin resistance already exists in glucose-tolerant Japanese NIDDM offspring.
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