Effect of glucagon-like peptide-1 on insulin secretion
K Shima, M Hirota, C Ohboshi - Regulatory peptides, 1988 - Elsevier
The insulinotropic actions of two forms of glucagon-like peptide 1 (GLP-1) containing 31 and
37 amino acid residues on perfused rat pancreas were compared with that of gastric
inhibitory polypeptide (GIP), hitherto the most potent intestinal insulinotropic polypeptide
known. The smaller form, C-terminally amidated GLP-1-(7–36), strongly enhanced insulin
secretion stimulated by 11.1 mM d-glucose at a concentration as low as 0.1 nM. Comparable
effects of GIP and GLP-1-(1–37) on insulin secretion were observed at concentrations of 1.0 …
37 amino acid residues on perfused rat pancreas were compared with that of gastric
inhibitory polypeptide (GIP), hitherto the most potent intestinal insulinotropic polypeptide
known. The smaller form, C-terminally amidated GLP-1-(7–36), strongly enhanced insulin
secretion stimulated by 11.1 mM d-glucose at a concentration as low as 0.1 nM. Comparable
effects of GIP and GLP-1-(1–37) on insulin secretion were observed at concentrations of 1.0 …