Pulsatile insulin has greater hypoglycemic effect than continuous delivery
DR Matthews, BA Naylor, RG Jones, GM Ward… - Diabetes, 1983 - Am Diabetes Assoc
DR Matthews, BA Naylor, RG Jones, GM Ward, RC Turner
Diabetes, 1983•Am Diabetes AssocThe relative hypoglycemic effects of pulsatile versus steadily infused insulin have been
examined in six normal subjects in whom pancreatic insulin output was suppressed by
somatostatin-14. Soluble insulin was infused continuously overnight on one occasion and
on another occasion the same quantity was given in pulses of 2-min duration with a gap of
11 min. The mean plasma glucose concentrations were lower when pulsed insulin was
given [mean for the last hour: 4.66±0.08 mmol/L (±SEM) versus 5.53±0.06 mmol/L (±SEM) …
examined in six normal subjects in whom pancreatic insulin output was suppressed by
somatostatin-14. Soluble insulin was infused continuously overnight on one occasion and
on another occasion the same quantity was given in pulses of 2-min duration with a gap of
11 min. The mean plasma glucose concentrations were lower when pulsed insulin was
given [mean for the last hour: 4.66±0.08 mmol/L (±SEM) versus 5.53±0.06 mmol/L (±SEM) …
The relative hypoglycemic effects of pulsatile versus steadily infused insulin have been examined in six normal subjects in whom pancreatic insulin output was suppressed by somatostatin-14. Soluble insulin was infused continuously overnight on one occasion and on another occasion the same quantity was given in pulses of 2-min duration with a gap of 11 min. The mean plasma glucose concentrations were lower when pulsed insulin was given [mean for the last hour: 4.66 ± 0.08 mmol/L (±SEM) versus 5.53 ± 0.06 mmol/L (±SEM) for steady infusion], diverging significantly (P < 0.05 paired t test) 7 h after the start of the study. The specific binding of 125I(A14)mono-iodo-insulin to monocytes was greater after pulsed insulin (2.9% with pulsed versus 2.4% with steadily infused insulin at tracer-only point; P < 0.02 paired t test). Thus, intravenous insulin has greater hypoglycemic effect when pulsed, possibly mediated by greater insulin receptor binding.
Am Diabetes Assoc