Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
are both incretin hormones regulating postprandial insulin secretion. Their relative
importance in this respect under normal physiological conditions is unclear, however, and
the aim of the present investigation was to evaluate this. Eight healthy male volunteers
(mean age: 23 (range 20–25) years; mean body mass index: 22.2 (range 19.3–25.4) kg/m2)
participated in studies involving stepwise glucose clamping at fasting plasma glucose levels …
are both incretin hormones regulating postprandial insulin secretion. Their relative
importance in this respect under normal physiological conditions is unclear, however, and
the aim of the present investigation was to evaluate this. Eight healthy male volunteers
(mean age: 23 (range 20–25) years; mean body mass index: 22.2 (range 19.3–25.4) kg/m2)
participated in studies involving stepwise glucose clamping at fasting plasma glucose levels …