[HTML][HTML] Targeting of big stanniocalcin and its receptor to lipid storage droplets of ovarian steroidogenic cells
M Paciga, CR McCudden, C Londos… - Journal of Biological …, 2003 - ASBMB
Stanniocalcin (STC) is a large polypeptide hormone that is widely distributed in tissues such
as kidney, adrenal, and ovary. In most tissues, STC exists as a 50-kDa homodimer (STC 50).
The ovaries produce a higher molecular weight variant (big STC) in androgen-producing
theca cell and interstitial cell compartments. Luteal cells, which do not express the STC
gene, nonetheless contain high levels of STC protein, suggesting they are targeted by and
sequester big STC through a receptor-mediated process. Recently, an STC· alkaline …
as kidney, adrenal, and ovary. In most tissues, STC exists as a 50-kDa homodimer (STC 50).
The ovaries produce a higher molecular weight variant (big STC) in androgen-producing
theca cell and interstitial cell compartments. Luteal cells, which do not express the STC
gene, nonetheless contain high levels of STC protein, suggesting they are targeted by and
sequester big STC through a receptor-mediated process. Recently, an STC· alkaline …