[HTML][HTML] Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node
TM Ishii, M Takano, LH Xie, A Noma… - Journal of Biological …, 1999 - ASBMB
We cloned a cDNA (HAC4) that encodes the hyperpolarization-activated cation channel (I f
or I h) by screening a rabbit sinoatrial (SA) node cDNA library using a fragment of rat brainI f
cDNA. HAC4 is composed of 1150 amino acid residues, and its cytoplasmic N-and C-
terminal regions are longer than those of HAC1–3. The transmembrane region of HAC4 was
most homologous to partially cloned mouse I f BCNG-3 (96%), whereas the C-terminal
region of HAC4 showed low homology to all HAC family members so far cloned. Northern …
or I h) by screening a rabbit sinoatrial (SA) node cDNA library using a fragment of rat brainI f
cDNA. HAC4 is composed of 1150 amino acid residues, and its cytoplasmic N-and C-
terminal regions are longer than those of HAC1–3. The transmembrane region of HAC4 was
most homologous to partially cloned mouse I f BCNG-3 (96%), whereas the C-terminal
region of HAC4 showed low homology to all HAC family members so far cloned. Northern …