Tissue-engineered skin: an alternative to split-thickness skin grafts?
TJ Phillips - Archives of dermatology, 1999 - jamanetwork.com
THE RESULTS of decades of research are now coming to fruition with the commercial
availability of skin substitutes in this country and throughout the world. In 1998, a human skin
equivalent (HSE)(Apligraf; Organogenesis Inc, Canton, Mass) consisting of a bilayered skin
construct of type 1 bovine collagen and live allogeneic human skin fibroblasts and
keratinocytes was approved in the United States for the treatment of venous ulcers based on
the data from a multicenter trial. 1 In this issue of the ARCHIVES, Muhart et al2 report the …
availability of skin substitutes in this country and throughout the world. In 1998, a human skin
equivalent (HSE)(Apligraf; Organogenesis Inc, Canton, Mass) consisting of a bilayered skin
construct of type 1 bovine collagen and live allogeneic human skin fibroblasts and
keratinocytes was approved in the United States for the treatment of venous ulcers based on
the data from a multicenter trial. 1 In this issue of the ARCHIVES, Muhart et al2 report the …