The fate of dendritic cells in a mouse model of liver ischemia/reperfusion injury
P Loi, F Paulart, B Pajak, N Nagy, I Salmon… - Transplantation …, 2004 - Elsevier
Ischemia/reperfusion during liver transplantation triggers a complex cascade of inflammatory
events that may lead to organ dysfunction. Herein, we investigated the consequences of
hepatic ischemia/reperfusion on liver dendritic cells. Liver damage was documented by
increased levels of serum alanine aminotransferase and by histopathology showing large
areas of hepatocyte cytolysis. MHC class II+ CD45-B220 F4/80 dendritic cells were detected
in necrotic areas 20 hours after reperfusion. Dendritic cells freshly isolated from reperfused …
events that may lead to organ dysfunction. Herein, we investigated the consequences of
hepatic ischemia/reperfusion on liver dendritic cells. Liver damage was documented by
increased levels of serum alanine aminotransferase and by histopathology showing large
areas of hepatocyte cytolysis. MHC class II+ CD45-B220 F4/80 dendritic cells were detected
in necrotic areas 20 hours after reperfusion. Dendritic cells freshly isolated from reperfused …