[HTML][HTML] SIRT1 is a circadian deacetylase for core clock components
WJ Belden, JC Dunlap - Cell, 2008 - cell.com
WJ Belden, JC Dunlap
Cell, 2008•cell.comThe transcriptional activator CLOCK is a histone acetyltransferase that is required for the
circadian expression of many genes. Asher et al.(2008) and Nakahata et al.(2008) now
demonstrate that the NAD+-dependent enzyme SIRT1 functions as a histone deacetylase
that counteracts the activity of CLOCK. These results broaden our understanding of the
impact of cellular metabolism on the circadian system.
circadian expression of many genes. Asher et al.(2008) and Nakahata et al.(2008) now
demonstrate that the NAD+-dependent enzyme SIRT1 functions as a histone deacetylase
that counteracts the activity of CLOCK. These results broaden our understanding of the
impact of cellular metabolism on the circadian system.
The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD+-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. These results broaden our understanding of the impact of cellular metabolism on the circadian system.
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