Intracerebroventricular administration of angiotensin type 1 (AT1) receptor antisense oligonucleotides attenuate thirst in the rat
RR Sakai, LY Ma, PF He, SJ Fluharty - Regulatory peptides, 1995 - Elsevier
The central actions of the peptide hormone angiotensin II (AngII) are importantly involved in
body fluid homeostasis. Included amongst these actions is a potent dipsogenic response
that has been implicated in the thirst that develops during many forms of extracellular
dehydration. The use of highly selective receptor antagonists has revealed that the Type 1
(AT1), and not the Type 2 (AT2), AngII receptor subtype mediates this drinking response.
More recently, antisense oligonucleotides specific for the AT1 receptor have been …
body fluid homeostasis. Included amongst these actions is a potent dipsogenic response
that has been implicated in the thirst that develops during many forms of extracellular
dehydration. The use of highly selective receptor antagonists has revealed that the Type 1
(AT1), and not the Type 2 (AT2), AngII receptor subtype mediates this drinking response.
More recently, antisense oligonucleotides specific for the AT1 receptor have been …