[HTML][HTML] Trafficking, ubiquitination, and down-regulation of the human platelet-activating factor receptor
DJ Dupré, Z Chen, C Le Gouill, C Thériault… - Journal of Biological …, 2003 - ASBMB
Platelet-activating factor (PAF) is a potent phospholipid mediator involved in various disease
states such as allergic asthma, atherosclerosis and psoriasis. The human PAF receptor
(PAFR) is a member of the G protein-coupled receptor family. Following PAF stimulation,
cells become rapidly desensitized; this refractory state can be maintained for hours and is
dependent on PAFR phosphorylation, internalization, and down-regulation. In this report, we
characterized ligand-induced, long term PAFR desensitization, and pathways leading to its …
states such as allergic asthma, atherosclerosis and psoriasis. The human PAF receptor
(PAFR) is a member of the G protein-coupled receptor family. Following PAF stimulation,
cells become rapidly desensitized; this refractory state can be maintained for hours and is
dependent on PAFR phosphorylation, internalization, and down-regulation. In this report, we
characterized ligand-induced, long term PAFR desensitization, and pathways leading to its …
