Dopamine and the kidney: a role in hypertension?
GRK4 single nucleotide polymorphisms, by preventing the natriuretic function of the
dopaminergic system and by allowing the antinatriuretic function of angiotensin II type 1
receptors to predominate, may be responsible for salt sensitivity. Hypertension develops
with additional perturbations caused by the variants of other genes (eg, α-adducin,
angiotensin converting enzyme, angiotensinogen, angiotensin II type 1 receptor,
aldosterone synthase, 11β-hydroxysteroid dehydrogenase type 2), the quantitative …
dopaminergic system and by allowing the antinatriuretic function of angiotensin II type 1
receptors to predominate, may be responsible for salt sensitivity. Hypertension develops
with additional perturbations caused by the variants of other genes (eg, α-adducin,
angiotensin converting enzyme, angiotensinogen, angiotensin II type 1 receptor,
aldosterone synthase, 11β-hydroxysteroid dehydrogenase type 2), the quantitative …
Summary
GRK4 single nucleotide polymorphisms, by preventing the natriuretic function of the dopaminergic system and by allowing the antinatriuretic function of angiotensin II type 1 receptors to predominate, may be responsible for salt sensitivity. Hypertension develops with additional perturbations caused by the variants of other genes (eg, α-adducin, angiotensin converting enzyme, angiotensinogen, angiotensin II type 1 receptor, aldosterone synthase, 11β-hydroxysteroid dehydrogenase type 2), the quantitative interaction of which may vary depending upon the genetic background.
Lippincott Williams & Wilkins