Concerted expression of eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells
A Komiya, H Nagase, H Yamada, T Sekiya… - Cellular …, 2003 - Elsevier
Eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26 bind specifically and exclusively
to CC chemokine receptor (CCR) 3, which is a potential therapeutic target in treating the
peribronchial eosinophilia associated with allergic airway diseases. Bronchial epithelial
cells represent an important source of chemokines, and thus we investigated in vitro and in
vivo expression of eotaxin-2 and eotaxin-3 in bronchial epithelial cells in comparison with
that of eotaxin-1. Immunohistochemistry showed increased expression of both eotaxin-2 and …
to CC chemokine receptor (CCR) 3, which is a potential therapeutic target in treating the
peribronchial eosinophilia associated with allergic airway diseases. Bronchial epithelial
cells represent an important source of chemokines, and thus we investigated in vitro and in
vivo expression of eotaxin-2 and eotaxin-3 in bronchial epithelial cells in comparison with
that of eotaxin-1. Immunohistochemistry showed increased expression of both eotaxin-2 and …
