On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors
RJ Gerson, JS MacDonald, AW Alberts, J Chen… - Experimental eye …, 1990 - Elsevier
The administration of high dosages of various hydroxymethylglutaryl-CoA (HMG-CoA)
reductase inhibitors has resulted in the development of subcapsular lenticualr opacities in
dogs. While dogs receiving cataractogenic doses of HMG-CoA reductase inhibitors
experienced profound decreases in circulating serum cholesterol concentrations (40–60%
reductions in total serum cholesterol), a causal relationship between serum cholesterol
lowering and cataractogenesis was not established. A strong relationship was …
reductase inhibitors has resulted in the development of subcapsular lenticualr opacities in
dogs. While dogs receiving cataractogenic doses of HMG-CoA reductase inhibitors
experienced profound decreases in circulating serum cholesterol concentrations (40–60%
reductions in total serum cholesterol), a causal relationship between serum cholesterol
lowering and cataractogenesis was not established. A strong relationship was …
