[HTML][HTML] Protein-protein interaction of retinoic acid receptor α and thyroid transcription factor-1 in respiratory epithelial cells
C Yan, A Naltner, J Conkright, M Ghaffari - Journal of Biological Chemistry, 2001 - ASBMB
Surfactant protein B (SP-B) is a 79-amino acid peptide critical to postnatal respiratory
adaptation and is developmentally regulated. Previous studies demonstrated that retinoic
acid receptors (RARs) and thyroid transcription factor 1 (TTF-1) stimulated SP-B gene
expression in respiratory epithelial cells. Clustered retinoic acid-responsive element and
TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were
required for retinoic acid stimulation of the human SP-B (hSP-B) promoter. In addition, RAR …
adaptation and is developmentally regulated. Previous studies demonstrated that retinoic
acid receptors (RARs) and thyroid transcription factor 1 (TTF-1) stimulated SP-B gene
expression in respiratory epithelial cells. Clustered retinoic acid-responsive element and
TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were
required for retinoic acid stimulation of the human SP-B (hSP-B) promoter. In addition, RAR …
