Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue
JB Fitzgerald, M Jin, AJ Grodzinsky - Journal of Biological Chemistry, 2006 - ASBMB
Chondrocytes are subjected to a variety of biophysical forces and flows during physiological
joint loading, including mechanical deformation, fluid flow, hydrostatic pressure, and
streaming potentials; however, the role of these physical stimuli in regulating chondrocyte
behavior is still being elucidated. To isolate the effects of these forces, we subjected intact
cartilage explants to 1–24 h of continuous dynamic compression or dynamic shear loading
at 0.1 Hz. We then measured the transcription levels of 25 genes known to be involved in …
joint loading, including mechanical deformation, fluid flow, hydrostatic pressure, and
streaming potentials; however, the role of these physical stimuli in regulating chondrocyte
behavior is still being elucidated. To isolate the effects of these forces, we subjected intact
cartilage explants to 1–24 h of continuous dynamic compression or dynamic shear loading
at 0.1 Hz. We then measured the transcription levels of 25 genes known to be involved in …
