Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity
RK Agarwal, SH Sun, SB Su, CC Chan… - Journal of …, 2002 - Elsevier
Pertussis toxin (PTX) is used to promote development of autoimmune diseases. The
mechanism (s) are still incompletely understood. We dissected the innate and adaptive
immune responses in a PTX-dependent model of autoimmune retinal disease, experimental
autoimmune uveoretinitis (EAU), a Th1-driven disease of the neural retina elicited in F344
rats with a peptide derived from the retinal antigen interphotoreceptor retinoid binding
protein (IRBP). Our results showed that optimal doses of PTX led to strongly increased …
mechanism (s) are still incompletely understood. We dissected the innate and adaptive
immune responses in a PTX-dependent model of autoimmune retinal disease, experimental
autoimmune uveoretinitis (EAU), a Th1-driven disease of the neural retina elicited in F344
rats with a peptide derived from the retinal antigen interphotoreceptor retinoid binding
protein (IRBP). Our results showed that optimal doses of PTX led to strongly increased …