Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
DL Lewis, JE Hagstrom, AG Loomis, JA Wolff… - Nature …, 2002 - nature.com
DL Lewis, JE Hagstrom, AG Loomis, JA Wolff, H Herweijer
Nature genetics, 2002•nature.comIt has recently been shown that RNA interference can be induced in cultured mammalian
cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient
in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific
inhibition of transgene expression in a variety of organs.
cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient
in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific
inhibition of transgene expression in a variety of organs.
Abstract
It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs.
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