[HTML][HTML] The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus
SJP Warren, LA Arteaga, LA Diaz, EA Rivitti… - Journal of investigative …, 2003 - Elsevier
Endemic pemphigus foliaceus, like the sporadic form seen in the developed world, is
mediated by IgG antibodies to desmoglein-1. We studied an endemic focus in Limao Verde,
Brazil, where disease prevalence is 3.4%. We previously detected IgG antibodies to
desmoglein-1 in 97% of patients, but also in 55% of normal subjects in the endemic focus,
with progressively lower levels in normal subjects in surrounding areas. An environmental
trigger is hypothesized to explain these and other findings. In this study we sought to …
mediated by IgG antibodies to desmoglein-1. We studied an endemic focus in Limao Verde,
Brazil, where disease prevalence is 3.4%. We previously detected IgG antibodies to
desmoglein-1 in 97% of patients, but also in 55% of normal subjects in the endemic focus,
with progressively lower levels in normal subjects in surrounding areas. An environmental
trigger is hypothesized to explain these and other findings. In this study we sought to …
The role of intramolecular epitope spreading in the pathogenesis of endemic pemphigus foliaceus (fogo selvagem)
N Li, V Aoki, G Hans-Filho, EA Rivitti… - The Journal of …, 2003 - rupress.org
We report here a relationship between intramolecular epitope spreading and the clinical
onset of the endemic form of pemphigus foliaceus in a Brazilian community with a high
prevalence and incidence of the disease. Also known as Fogo Selvagem (FS), this disease
is characterized by severe skin blistering and pathogenic anti–desmoglein-1 (Dsg1)
autoantibodies. These autoantibodies bind the Dsg1 ectodomain and trigger keratinocyte
cell detachment, the hallmark of FS. We show that (a) sera from FS patients in the preclinical …
onset of the endemic form of pemphigus foliaceus in a Brazilian community with a high
prevalence and incidence of the disease. Also known as Fogo Selvagem (FS), this disease
is characterized by severe skin blistering and pathogenic anti–desmoglein-1 (Dsg1)
autoantibodies. These autoantibodies bind the Dsg1 ectodomain and trigger keratinocyte
cell detachment, the hallmark of FS. We show that (a) sera from FS patients in the preclinical …
