Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory diseases

M Ballow - Journal of allergy and clinical immunology, 1997 - Elsevier
Intravenous immune serum globulin (IVIG) is primarily used as replacement therapy in
patients with hypogammaglobulinemia. It has been over 15 years since IVIG was first shown
to be effective in the treatment of patients with autoimmune thrombocytopenic purpura. Over
the past decade, IVIG has been used in the treatment of a number of autoimmune and
systemic inflammatory disorders. Although the use of IVIG in many of these immune-
mediated disorders was purely speculative initially, we now have a much better …