Eph receptors and their cognate ligand ephrins play important roles in various biological
processes such as cell migration, axon guidance, and synaptic plasticity. One characteristic
feature of the Eph-ephrin signal transduction is that, upon interaction with the receptor, the
transmembrane B-class ephrins become tyrosine-phosphorylated and transduce
intracellular signals that lead to reorganization of the cytoskeleton. Although in vitro and
genetic studies have demonstrated unequivocally the significance of this reverse signaling …