[HTML][HTML] Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase
The Eph family of receptor protein tyrosine kinases (RPTKs) is the largest family of RPTKs.
The signal transduction pathways initiated by this family have only recently begun to be
explored. Using a yeast two-hybrid screen to identify molecules that interact with the
cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and
stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, DF, Saltiel, AR, and Dixit, VM
(1994) J. Biol. Chem. 269, 30154-30157). Also isolated [Abstract] from this same screen was …
The signal transduction pathways initiated by this family have only recently begun to be
explored. Using a yeast two-hybrid screen to identify molecules that interact with the
cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and
stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, DF, Saltiel, AR, and Dixit, VM
(1994) J. Biol. Chem. 269, 30154-30157). Also isolated [Abstract] from this same screen was …