Signal transduction downstream of tyrosine kinases has become an increasingly important
area of study in cardiovascular biology. In this review, we consider the experimental
evidence pointing to significant roles for the Axl receptor tyrosine kinase and its ligand,
Gas6, in the vasculature. An introduction to the Gas6/Axl system and a discussion of its
discovery is followed by a summary of the data regarding expression of Gas6/Axl in injured
arteries. We conclude by discussing mechanisms by which Gas6/Axl signaling may impact …