Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells
Accumulation of low-density lipoprotein (LDL)-derived cholesterol by macrophages in vessel
walls is a pathogenomic feature of atherosclerotic lesions. Platelets contribute to lipid uptake
by macrophages through mechanisms that are only partially understood. We have
previously shown that platelet factor 4 (PF4) inhibits the binding and degradation of LDL
through its receptor, a process that could promote the formation of oxidized LDL (ox-LDL).
We have now characterized the effect of PF4 on the binding of ox-LDL to vascular cells and …
walls is a pathogenomic feature of atherosclerotic lesions. Platelets contribute to lipid uptake
by macrophages through mechanisms that are only partially understood. We have
previously shown that platelet factor 4 (PF4) inhibits the binding and degradation of LDL
through its receptor, a process that could promote the formation of oxidized LDL (ox-LDL).
We have now characterized the effect of PF4 on the binding of ox-LDL to vascular cells and …
