[HTML][HTML] STAT3 is constitutively active in some patients with Polycythemia rubra vera
S Röder, C Steimle, G Meinhardt, HL Pahl - Experimental hematology, 2001 - Elsevier
OBJECTIVE: Polycythemia vera is a clonal stem cell disorder characterized by
hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages. While it has been
shown that progenitor cells of P. vera patients are hypersensitive to several growth factors
including erythropoietin, insulin-like growth factor-1, thrombopoietin, interleukin-3, and
granulocyte/monocyte colony-stimulating factor, the molecular pathogenesis of this disease
remains unknown. Growth factor hypersensitivity could be mediated by changes in signal …
hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages. While it has been
shown that progenitor cells of P. vera patients are hypersensitive to several growth factors
including erythropoietin, insulin-like growth factor-1, thrombopoietin, interleukin-3, and
granulocyte/monocyte colony-stimulating factor, the molecular pathogenesis of this disease
remains unknown. Growth factor hypersensitivity could be mediated by changes in signal …
