[HTML][HTML] Engagement of integrin α4β1 enhances thrombopoietin-induced megakaryopoiesis
NE Fox, K Kaushansky - Experimental hematology, 2005 - Elsevier
OBJECTIVE: Studies in numerous adherent cell systems have indicated that engagement of
integrins is required for cell survival and proliferation. Although not classically thought of as
an adherent cell type, megakaryocytes in the marrow develop in juxtaposition to endothelial
cells which display a number of integrin counter-receptors. Moreover, a number of other
hematopoietic cell types, including stem cells and erythroid progenitors, have been shown to
engage and be affected by integrin ligands. METHODS: The role of β1 integrins in …
integrins is required for cell survival and proliferation. Although not classically thought of as
an adherent cell type, megakaryocytes in the marrow develop in juxtaposition to endothelial
cells which display a number of integrin counter-receptors. Moreover, a number of other
hematopoietic cell types, including stem cells and erythroid progenitors, have been shown to
engage and be affected by integrin ligands. METHODS: The role of β1 integrins in …
