Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
FJ De Sauvage, PE Hass, SD Spencer, BE Malloy… - Nature, 1994 - nature.com
FJ De Sauvage, PE Hass, SD Spencer, BE Malloy, AL Gurney, SA Spencer, WC Darbonne…
Nature, 1994•nature.comPhysiological platelet synthesis is thought to require the humoral activities of meg-CSF and
thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic
cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has
been purified and cloned. This protein binds to and activates the c-mpl protein, a member of
the cytokine receptor superfamily. The isolated Mpl ligand shares homology with
erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic
cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has
been purified and cloned. This protein binds to and activates the c-mpl protein, a member of
the cytokine receptor superfamily. The isolated Mpl ligand shares homology with
erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
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