[HTML][HTML] Of mice and men: comparison of the ultrastructure of megakaryocytes and platelets
A Schmitt, J Guichard, JM Massé, N Debili… - Experimental …, 2001 - Elsevier
OBJECTIVE: Mice provide an excellent model for studying platelet and megakaryocyte (Mk)
biology in vivo. Given the increasing use of transgenic and knockout mice, it is important that
any similarities and differences between murine and human platelet/Mk biology be well
defined. Therefore the objective of this study was to compare and contrast in detail any
significant morphological differences between Mks, platelets, and mechanisms of
thrombopoiesis in humans and mice. METHODS: The distinctive structural and …
biology in vivo. Given the increasing use of transgenic and knockout mice, it is important that
any similarities and differences between murine and human platelet/Mk biology be well
defined. Therefore the objective of this study was to compare and contrast in detail any
significant morphological differences between Mks, platelets, and mechanisms of
thrombopoiesis in humans and mice. METHODS: The distinctive structural and …
