Potential impact of selective cyclooxygenase-2 inhibitors on bone metabolism in health and disease
LG Raisz - The American journal of medicine, 2001 - Elsevier
Prostaglandins are potent local regulators of bone cell function and may play a critical role in
both physiologic and pathologic changes in the human skeleton. The availability of
cyclooxygenase-2 (COX-2)–specific inhibitors, which are likely to be used frequently and for
long periods because of their improved safety profile, mandates an investigation of their
possible effects on bone. This is particularly important in older individuals, who are at risk of
developing bone loss as a result of estrogen deficiency and aging. This review describes the …
both physiologic and pathologic changes in the human skeleton. The availability of
cyclooxygenase-2 (COX-2)–specific inhibitors, which are likely to be used frequently and for
long periods because of their improved safety profile, mandates an investigation of their
possible effects on bone. This is particularly important in older individuals, who are at risk of
developing bone loss as a result of estrogen deficiency and aging. This review describes the …
