[HTML][HTML] Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins
DG Winkler, MSK Sutherland, E Ojala, E Turcott… - Journal of Biological …, 2005 - ASBMB
High bone mass diseases are caused both by activating mutations in the Wnt pathway and
by loss of SOST, a bone morphogenetic protein (BMP) antagonist, leading to the activation
of BMP signaling. Given the phenotypic similarity between mutations that activate these
signaling pathways, it seems likely that BMPs and Wnts operate in parallel or represent
components of the same pathway, modulating osteoblast differentiation. In this study, we
show that in C3H10T1/2 cells, Wnt-3A and BMP-6 proteins were inducers of osteoblast …
by loss of SOST, a bone morphogenetic protein (BMP) antagonist, leading to the activation
of BMP signaling. Given the phenotypic similarity between mutations that activate these
signaling pathways, it seems likely that BMPs and Wnts operate in parallel or represent
components of the same pathway, modulating osteoblast differentiation. In this study, we
show that in C3H10T1/2 cells, Wnt-3A and BMP-6 proteins were inducers of osteoblast …
