Osteoporosis is a complex multi-factorial disease where environment, diet and genetics play
a role in determining susceptibility. Patients with existing vertebral fracture have a
heightened risk of further recurrent vertebral fracture. The efficacy of new osteoporosis
therapies is often compared to calcium supplementation. 1, 25-dihydroxyvitamin D 3
(calcitriol) acts through the vitamin D receptor (VDR) and is effective at reducing recurrent
vertebral fracture risk. Because the VDR controls calcium metabolism, we hypothesized that …