[HTML][HTML] Pain perception in mice lacking the β3 subunit of voltage-activated calcium channels
M Murakami, B Fleischmann, C De Felipe… - Journal of Biological …, 2002 - ASBMB
The importance of voltage-activated calcium channels in pain processing has been
suggested by the spinal antinociceptive action of blockers of N-and P/Q-type calcium
channels as well as by gene targeting of the α1B subunit (N-type). The accessory β3
subunits of calcium channels are preferentially associated with the α1B subunit in neurones.
Here we show that deletion of the β3 subunit by gene targeting affects strongly the pain
processing of mutant mice. We pinpoint this defect in the pain-related behavior and …
suggested by the spinal antinociceptive action of blockers of N-and P/Q-type calcium
channels as well as by gene targeting of the α1B subunit (N-type). The accessory β3
subunits of calcium channels are preferentially associated with the α1B subunit in neurones.
Here we show that deletion of the β3 subunit by gene targeting affects strongly the pain
processing of mutant mice. We pinpoint this defect in the pain-related behavior and …