[HTML][HTML] Stimulus-transcription coupling in pheochromocytoma cells: promoter region-specific activation of chromogranin a biosynthesis
K Tang, H Wu, SK Mahata, L Taupenot… - Journal of Biological …, 1996 - ASBMB
To explore stimulus-transcription coupling in pheochromocytoma cells, we studied the
biosynthetic response of chromogranin A, the major soluble protein co-stored and co-
released with catecholamines, to chromaffin cells' physiologic nicotinic cholinergic secretory
stimulation. Chromogranin A mRNA showed a time-dependent 3.87-fold response to
nicotinic stimulation, and a nuclear run-off experiment indicated that the response occurred
at a transcriptional level. Transfected chromogranin A promoter/luciferase reporter …
biosynthetic response of chromogranin A, the major soluble protein co-stored and co-
released with catecholamines, to chromaffin cells' physiologic nicotinic cholinergic secretory
stimulation. Chromogranin A mRNA showed a time-dependent 3.87-fold response to
nicotinic stimulation, and a nuclear run-off experiment indicated that the response occurred
at a transcriptional level. Transfected chromogranin A promoter/luciferase reporter …