Catestatin (CgA344–364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides
PG Krüger, SK Mahata, KB Helle - Regulatory peptides, 2003 - Elsevier
Catestatin (bovine CgA344–364) is a cationic peptide, which besides reducing
catecholamine secretion from chromaffin cells in vitro also acts a potent vasodilator in the rat
in vivo. The alleged histamine releasing effect of catestatin was tested in vitro in rat mast
cells. The most active domain of catestatin (bovine CgA344–358: RSMRLSFRARGYGFR)
caused concentration-dependent (0.01–5 μM) release of histamine from peritoneal and
pleural mast cells. The potency and efficacy of catestatin was higher than for the wasp …
catecholamine secretion from chromaffin cells in vitro also acts a potent vasodilator in the rat
in vivo. The alleged histamine releasing effect of catestatin was tested in vitro in rat mast
cells. The most active domain of catestatin (bovine CgA344–358: RSMRLSFRARGYGFR)
caused concentration-dependent (0.01–5 μM) release of histamine from peritoneal and
pleural mast cells. The potency and efficacy of catestatin was higher than for the wasp …
