Stimulation of chromaffin cell secretion in vitro triggers not only secretion but also
resynthesis of just released catecholamines and chromogranin A, the precursor of the
catecholamine release-inhibitory, nicotinic cholinergic antagonist peptide catestatin. Does
stimulus-transcription coupling occur in vivo? And does catestatin antagonize secretion and
transcription in vivo? To answer these questions, we employed a novel mouse strain
harboring a chromogranin A promoter/firefly luciferase reporter transgene. Tissue-specific …