[HTML][HTML] Desensitization of catecholamine release: the novel catecholamine release-inhibitory peptide catestatin (chromogranin A344–364) acts at the receptor to …
SK Mahata, M Mahata, RJ Parmer… - Journal of Biological …, 1999 - ASBMB
Nicotinic cholinergic receptors undergo desensitization upon repeated or prolonged
exposure to agonist. We investigated the effects of a novel chromogranin A catecholamine
release-inhibitory fragment, catestatin (chromogranin A 344–364), on agonist-induced
desensitization of catecholamine release from pheochromocytoma cells. In a dose-
dependent fashion, the nicotinic antagonist catestatin blocked agonist desensitization of
both catecholamine release (IC 50∼ 0.24 μm) and 22 Na+ uptake (IC 50∼ 0.31 μm), the …
exposure to agonist. We investigated the effects of a novel chromogranin A catecholamine
release-inhibitory fragment, catestatin (chromogranin A 344–364), on agonist-induced
desensitization of catecholamine release from pheochromocytoma cells. In a dose-
dependent fashion, the nicotinic antagonist catestatin blocked agonist desensitization of
both catecholamine release (IC 50∼ 0.24 μm) and 22 Na+ uptake (IC 50∼ 0.31 μm), the …