Identification of a novel set of genes regulated by a unique liver X receptor-α-mediated transcription mechanism
LM Anderson, SE Choe, RY Yukhananov… - Journal of Biological …, 2003 - ASBMB
We have reported previously that liver X receptor-α (LXRα) can mediate a novel cAMP-
dependent increase in renin and c-myc gene transcription by binding as a monomer to a
unique regulatory element termed the cAMP-negative response element (CNRE). To
determine whether this novel action of LXRα has global implications on gene regulation, we
employed expression profiling to identify other genes regulated by this unique mechanism.
Here we report the existence of a set of known and unknown transcripts regulated in parallel …
dependent increase in renin and c-myc gene transcription by binding as a monomer to a
unique regulatory element termed the cAMP-negative response element (CNRE). To
determine whether this novel action of LXRα has global implications on gene regulation, we
employed expression profiling to identify other genes regulated by this unique mechanism.
Here we report the existence of a set of known and unknown transcripts regulated in parallel …
