Preferential expression of TCR Vα regions in CD4/CD8 subsets: class discrimination or co-receptor recognition?
BC Sim, D Lo, NRJ Gascoigne - Immunology today, 1998 - cell.com
BC Sim, D Lo, NRJ Gascoigne
Immunology today, 1998•cell.comThe preferential expression of T-cell receptor (TCR) Vα regions in the CD4+ and CD8+ T-
cell subsets suggests that they have a special role in distinguishing recognition of major
histocompatibility complex (MHC) class I from class II, or CD4 from CD8. Here, Bee-Cheng
Sim, David Lo and Nicholas Gascoigne review recent data indicating the molecular basis for
this discrimination, and how polymorphism within Vα subfamilies and between TCR α-chain
haplotypes contributes to the T-cell repertoire.
cell subsets suggests that they have a special role in distinguishing recognition of major
histocompatibility complex (MHC) class I from class II, or CD4 from CD8. Here, Bee-Cheng
Sim, David Lo and Nicholas Gascoigne review recent data indicating the molecular basis for
this discrimination, and how polymorphism within Vα subfamilies and between TCR α-chain
haplotypes contributes to the T-cell repertoire.
Abstract
The preferential expression of T-cell receptor (TCR) Vα regions in the CD4+ and CD8+ T-cell subsets suggests that they have a special role in distinguishing recognition of major histocompatibility complex (MHC) class I from class II, or CD4 from CD8. Here, Bee-Cheng Sim, David Lo and Nicholas Gascoigne review recent data indicating the molecular basis for this discrimination, and how polymorphism within Vα subfamilies and between TCR α-chain haplotypes contributes to the T-cell repertoire.
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